WEBINAR SERIES
Investigating Strategies for Microbial Screening of E. Coli and P. Pastoris for Bioprocess Scale-up Using a Parallel-format, Plate-based Microbioreactor
Methods for microbial screening have advanced greatly in the last few years. In this study, we will investigate a parallel format, plate-based, microbioreactor to perform DO triggered fed-batch experiments to screen E. coli and P. pastoris strains to elucidate which clones are the best 1.) growers and 2.) best growers/producers. We de-risked our larger scale/larger volume, more expensive systems, and obtained the high value experimental parameters at 1mL required for our bio-process scale up. We were able to observe experimental nuances not visible or detectable in our other platforms by cost effectively increasing our data density which provided a better understanding of our fermentation parameters for each individual clone, media, vector. In our experience, the BioLector platform provided the same performance as industrial scale bioreactors.
In this webinar, attendees will learn:
- To perform cost effective microbial screening or bioprocess development in the lab
- The advantage of microfermentations for later scale-up experiments
- The calculation of high-throughput plus data quality equals micro-scale costs
Presenter:
Jeff Thornton, Director, North and South America, m2p-labs
Jeff Thornton is the Director of m2p-labs, Inc., North and South America, a micro-bioreactor company engaged in fermentation-based research and development of high throughput micro-bioreactor technologies. Prior to joining m2p-labs, Jeff was a technical scientist for TECAN Inc., Molecular Devices (Danaher), Bio-Rad Laboratories and Sequenom Inc. Previously, Jeff was an Application Scientist and the Asia-Pacific Applications Manager for Sequenom Inc., residing in Asia and supporting a worldwide install base. Jeff was employed as a Research Scientist for Nexell Therapeutics, Reprogen, Inc., Bio-Rad Laboratories and Nichols Institute (Quest Diagnostics). Jeff graduated from the University of California, Santa Barbara with a Bachelor of Science degree in Biological Sciences in 1991.
Date: December 2, 2020
Time: 1:00 pm Central Daylight
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